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Am. J. Trop. Med. Hyg., 23(5), 1974, pp. 915-918
Copyright © 1974 by The American Society of Tropical Medicine and Hygiene

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Suppression of Schistosome Granuloma Formation by Malaria in Mice*

Mohamed F. Abdel-Wahab, Kendall G. Powers, Samiha S. Mahmoud{dagger} AND William C. Good
Howard University, Washington, D.C. 20001, and National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014

Plasmodium berghei yoelii infection in mice suppressed granuloma formation around Schistosoma mansoni eggs in the lungs. This suppressive effect was observed as early as 4 days after schistosome eggs were injected into malaria-infected mice and the maximum suppressive effect was seen by the 16th day. At that time granulomas in control mice were 58% larger than those observed in marlaria-infected mice. In addition, granuloma formation was found more consistently in control mice than in mice infected with malaria. These data suggest that malaria has a direct influence on an immunologic reaction of the delayed hypersensitivity type. There was no significant difference in the level of antibodies, specific for schistosome eggs, in the sera of the malaria-infected mice as compared to mice injected with S. mansoni eggs alone.

Accepted for publication December 29, 1973.


* Address reprint requests to: Dr. Kendall G. Powers, Laboratory of Parasitic Diseases, NIAID, National Institutes of Health, Bethesda, Maryland 20014.


{dagger} On leave of absence from the Tropical Research Institute, Cairo.




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[Abstract] [Full Text] [PDF]


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Copyright © 1974 by the American Society of Tropical Medicine and Hygiene.