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Am. J. Trop. Med. Hyg., 23(5), 1974, pp. 895-898
Copyright © 1974 by The American Society of Tropical Medicine and Hygiene

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Arrested Development in Ancylostoma Duodenale: Course of a Self-Induced Infection in Man*

T. A. Nawalinski{dagger} AND G. A. Schad{dagger}
Department of Pathobiology, School of Hygiene and Public Health, The Johns Hopkins University, Baltimore, Maryland 21205

The course of a self-induced infection with about 100 Ancylostoma duodenale larvae was followed by twice-weekly blood and stool examinations. After a small initial increase, no further change in eosinophil counts occurred until the 33rd week of infection when they began to increase sharply. Seven weeks later, eggs were first observed in stools. Thus, in this infection, the prepatent period was five times the expected. It is suggested that a strain of A. duodenale exists which either 1) has an inherent, abnormally long prepatent period or 2) has a prepatent period which is susceptible to change depending upon the environmental conditions experienced by the free-living larvae. In either case, the third stage larvae probably enter a hypobiotic state within the host which lasts for about 8 months.

Accepted for publication February 16, 1974.


* Supported by Grants 5 T01 AI00020-15, 5 R07 TW 00141-05, and AI 10848 from the National Institute of Allergy and Infectious Diseases.


{dagger} Present address: University of Pennsylvania, School of Veterinary Medicine, Department of Pathobiology, 3800 Spruce Street, Philadelphia, Pennsylvania 19174.




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Copyright © 1974 by the American Society of Tropical Medicine and Hygiene.