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Human Infections with Chagres Virus in Panama

Clinical and prevalence studies of Chagres virus (Phlebotomus-fever group of arboviruses) infections in Panamanian residents were performed. Clinical cases of Chagres virus infection in three persons are described. Antibody conversions and virus reisolations were demonstrated in all cases. The distribution of Chagres hemagglutination-inhibition antibodies in different regions of Panama were as follows: western region 0.4% of 1,329 samples; central region 4.3% of 2,829; eastern region 2.9% of 276; Perlas Islands 10.9% of 174 (including 17.8% of 107 from San Miguel Island), giving an overall rate of 3.3% in 4,608 samples. These results indicate a widespread distribution of Chagres virus in Panama, with a particularly high rate of antibody prevalence on one of the offshore islands.

Accepted for publication December 1, 1973.

^* Present address: Division of Laboratories, New Jersey State Department of Health, P. O. Box 1540, Trenton, New Jersey 08625.