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Severe Intrahepatic Cholestasis due to Thiabendazole

A 32-year-old woman developed severe and protracted intrahepatic cholestasis following the oral ingestion of thiabendazole (Mintezol®). The cholestatic reaction was associated with nausea, intense pruritus, and a generalized rash. The jaundice persisted for more than 1 month without signs of remission. A transhepatic cholangiogram was followed by a massive hemorrhage which ultimately led to her death. Postmortem examination revealed completely patent ducts and liver histology was indicative of a cholestatic drug reaction. Cholestasis due to hypersensitivity to thiabendazole has not previously been reported.

Accepted for publication December 8, 1973.

^* Dr. Freston is a Burroughs Wellcome Scholar in Clinical Pharmacology.