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Intraspecific Variation in Plasmodium Falciparum^*

Significant structural differences are observed between the chloroquine-resistant Vietnam (Smith) strain and the chloroquine-sensitive Malaya (Camp-Sadun) strain of Plasmodium falciparum. The Vietnam strain shows subpellicular microtubules in the gametocyte, granular aggregates of the nucleus and enlargement of food vacuoles in the gametocyte and asexual form, while the Malaya (Camp-Sadun) strain lacks such findings. These differences are attributable to genetic variation rather than to drug resistance.

Accepted for publication November 17, 1973.

^* This paper is contribution number 1199 from the Army Research Program on Malaria. Part of this study was supported by the U.S. Army Medical Research and Development Command under Contract No. DADA 17-70-C-0006 and a Research Grant (AI-08970) from the U. S. Public Health Service. The senior author is a Research Career Development Awardee (AI-46237) of the U. S. Public Health Service.

This material has been reviewed by the Walter Reed Army Institute and there is no objection to its presentation and/or publication. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense.