HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Segal, H. E. Articles by Castaneda, B. F. Search for Related Content PubMed PubMed Citation Articles by Segal, H. E. Articles by Castaneda, B. F.

Preliminary Study of WR 33063 in the Treatment of Falciparum Malaria in Northeast Thailand^*

Herbert E. Segal, Prem Chinvanthananond, Bunharn Laixuthai, Pung Phintuyothin, Eliot J. Pearlman, Amporn Na-Nakorn AND Ben F. Castaneda

A clinical trial comparing the efficacy and toxicity of WR 33063, a phenanthrenemethanol derivative, and quinine sulfate, was undertaken in adult Thai males with Plasmodium falciparum infections hospitalized in Prachinburi, Thailand. A 6-day course of WR 33063, 1.8 g daily, in divided doses, cured 23 of 25 patients. Quinine sulfate, in a course of 1.95 g daily in divided doses for 6 days, cured 21 of 22 patients. WR 33063 treatment was accompanied by a smaller number of side effects than treatment with quinine sulfate. Hematologic and biochemical abnormalities were not detected during or following treatment with either drug. An extended trial of WR 33063 and WR 30090, a quinolinemethanol derivative, is in progress.

Accepted for publication December 1, 1973.

^* This is contribution number 1216 to the Army Research Program on Malaria.

Present address: Division of Preventive Medicine, Walter Reed Army Institute of Research, Washington, D. C. 20012.