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Urine Tests to Monitor the Self-Administration of Dapsone by Leprosy Patients^*

Three qualitative and one simple quantitative urine test methods are described for monitoring the self-administration of daily doses of dapsone (DDS) by leprosy patients. The qualitative methods can be employed for monitoring the taking of daily doses of 50 mg DDS or more. In the quantitative method the ratio of DDS plus its diazotizable metabolites to creatinine in the urine is determined using simple colorimetric methods. This method is considerably more sensitive and efficient than the qualitative methods and is capable of monitoring the taking of daily doses of DDS of as little as 10 mg.

Accepted for publication September 29, 1973.

^* Address reprint requests to: Dr. G. A. Ellard, MRC Unit for Laboratory Studies of Tuberculosis, Royal Postgraduate Medical School, London W12 OHS, England.