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Am. J. Trop. Med. Hyg., 23(3), 1974, pp. 400-403
Copyright © 1974 by The American Society of Tropical Medicine and Hygiene

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Renal Changes in Mice Infected with Schistosoma Mansoni*

Zilton A. Andrade AND Myron Susin
Departments of Pathology, University of Bahia School of Medicine, Salvador, Bahia, Brazil, and Cornell University Medical College, New York, New York 10021

Electron dense deposits in mesangial areas and on the glomerular basement membrane, plus the presence of immunoglobulin (IgG) in the same locations, were observed in the kidneys of mice heavily infected with Schistosoma mansoni. When examined by light microscopy, these kidneys were within normal limits. It thus seems that with appropriate techniques the mouse model will prove useful for future studies on the problem of renal involvement in schistosomiasis.

Accepted for publication September 15, 1973.


* This study was supported in part by the National Institutes of Health General Research Support Grant No. 5-S01-RR05396-11, and the Commonwealth Fund.






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Copyright © 1974 by the American Society of Tropical Medicine and Hygiene.