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Combined Chloroquine-Primaquine Therapy against Vivax Malaria^*

Peter G. Contacos, William E. Collins, William Chin, Marvin H. Jeter AND Peter E. Briesch

The efficacy of the therapeutic regimen consisting of eight weekly doses of combined chloroquine-primaquine was evaluated against a South Victnam (SV) strain of vivax malaria and Chesson strain vivax. The chloroquine was given at a dose of 300 mg base and the primaquine at 45 mg base. Against the SV strain of vivax there was a protective rate of 90% and a radical curative rate of 100% for this therapeutic regimen. The efficacy against Chesson strain vivax was lower. Relapse pattern characteristics on the SV strain are presented.

Accepted for publication October 13, 1973.

^* Address reprint requests to: Laboratory of Parasitic Diseases, Building 5, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014.

Formerly Head, Section on Primate Malaria, Laboratory of Parasitic Diseases, National Institutes of Health, Atlanta-Chamblee, Georgia.