AJTMH HINARI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am. J. Trop. Med. Hyg., 23(2), 1974, pp. 222-230
Copyright © 1974 by The American Society of Tropical Medicine and Hygiene

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Peters, J. H.
Right arrow Articles by Kirchheimer, W. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Peters, J. H.
Right arrow Articles by Kirchheimer, W. F.

Metabolic Disposition of Dapsone in Patients with Dapsone-Resistant Leprosy*

J. H. Peters, G. R. Gordon, L. Levy, M. A. Storkan, R. R. Jacobson, C. D. Enna AND W. F. Kirchheimer
Stanford Research Institute, Menlo Park, California 94025, Public Health Service Hospital, San Francisco, California 94118, Public Health Service Outpatient Clinic, San Pedro, California 90731, and Public Health Service Hospital, Carville, Louisiana 70721

To investigate the question of whether dapsone (DDS) resistance in leprosy patients is related to the metabolic disposition of DDS, we studied a group of 22 patients who had relapsed with DDS-resistant disease after approximately 19 years of sulfone therapy. Tests for acetylator phenotype with sulfamethazine (SMZ) showed that this group of patients contained a lower percentage of slow and a higher percentage of intermediate and rapid acetylators than had been observed previously in other populations. Acetylation of SMZ and DDS were directly related. In addition, plasma clearance of DDS for the DDS-resistant group was significantly faster than that found previously in any other population. These observations suggest that the emergence of DDS resistance may be associated with the rapid or intermediate acetylator phenotype and an ability to clear DDS from the circulation at a fast rate. Combining the two parameters into a multirisk factor yielded a significantly higher mean value in DDS-resistant patients than that of any other group studied previously. The implications of these findings for the large-scale treatment of leprosy patients are discussed.

Accepted for publication July 28, 1973.


* Supported in part by the United States-Japan Cooperative Medical Science Program administered by the National Institute of Allergy and Infectious Diseases (Grant R22 AI 08214 and Contract NIH 70-2283), National Institutes of Health, Department of Health, Education and Welfare.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1974 by the American Society of Tropical Medicine and Hygiene.