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Delayed Hypersensitivity in Ugandan Schistosomiasis Mansoni

III. Examination of Serological Responses and Clinical States^*

Pamela L. Moriearty AND Robert M. Lewert

Serological responses and clinical states of 15 subjects with overt Schistosoma mansoni infection and delayed hypersensitivity (DHS) to adult worm antigen were compared with responses in 15 subjects with overt infection, but negative delayed skin reactions. Subjects selected were paired as closely as possible in sex, age, quantitative S. mansoni fecal egg counts, history of treatment for S. mansoni and length of residence in a nonendemic area. Pair members differed in that one member had a positive reaction 24 hours after skin testing, while the other did not. DHS was not associated with any significant differences in levels of serum IgA, IgM, IgG or IgE; in complement fixation or indirect fluorescent antibody titers; or in presence of positive circumoval precipitin test. Presence of lines in the micro-Ouchterlony double diffusion test was significantly more common in subjects with DHS, but other investigations in this laboratory have shown that the presence of precipitin lines in this test is not unique to sera from subjects with DHS. The presence of DHS was not associated with any detectable differences in clinical state of the subject or in presence of liver or spleen enlargement.

Accepted for publication August 18, 1973.

^* These investigations have been supported in major part by United States Public Health Service-National Institute of Allergy and Infectious Diseases Grant No. AI 00884 and in part by the United States-Japan Cooperative Medical Science Program Grant AI 07724, and by a travel grant from the Rockefeller Foundation: Biomedical Sciences Grant No. GA MNS 6952.

Address reprint requests to: Dr. Robert M. Lewert, University of Chicago, Department of Microbiology, Cummings Life Sciences Center, 920 East 58th Street, Chicago, Illinois 60637.

Trainee, United States Public Health Service Training Grant No. AI 00331.