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Morphologically Altered Eggs of Trichuris Trichiura Following Treatment with Mebendazole^*

As early as 1 day following the administration of mebendazole to 14 patients for the treatment of Trichuris trichiura infections, the eggs of this worm were observed to be abnormal in size, shape and color. Some of the morphological changes are: increased size, the presence of a membrane, distorted configuration by elongation, distorted shape of the polar plugs, abnormal number of polar plugs, decrease in size, and abnormal yolk material which is refractive to bile staining and development to the larval stage. Some abnormal eggs with normal-appearing yolk material developed to motile larvae.

Accepted for publication July 21, 1973.

^* This work was done at the facilities of the Louisiana State University International Center for Medical Research and Training in San José, Costa Rica and at the Hospital San Juan de Dios and the Hospital Nacional de Niños.