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In Vivo Effects of a New Anthelmintic, Mebendazole (R-17,635) on the Eggs of Trichuris Trichiura and Hookworm^*

Mebendazole, a highly effective broad-spectrum anthelmintic, was tested for its in vivo effects on the eggs of Trichuris trichiura and hookworm recovered from patients treated with the drug. A marked reduction of the number of eggs that developed to the larval stage was observed for the eggs of both nematode species. The mean pre-treatment percentage of incubated whipworm eggs that developed to larvae was 81.7. One day following the initiation of treatment the mean percentage was 67.1. On day 2 the number was 1.4%, on day 3 it was 0.1%, and no eggs developed on day 4 and thereafter. The mean figure for incubated hookworm eggs in pre-treatment stools was 84.4% larval development. One day after treatment was started, 51.4% of the eggs collected in the stools and incubated were observed to develop. No eggs developed to the larval stage beyond day 1 following the start of treatment. Mebendazole has a highly ovicidal effect in treated patients.

Accepted for publication July 21, 1973.

^* This work was done at the facilities of the Louisiana State University International Center for Medical Research and Training in San José, Costa Rica, and at the Hospital San Juan de Dios and the Hospital Nacional de Niños.