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Dermal Sensitivity to Paracoccidioidin and Histoplasmin in Family Members of Patients with Paracoccidioidomycosis^*

Transmission of paracoccidioidomycosis infection from the patient to close family members has been indicated by comparing dermal sensitivity reactions to paracoccidioidin and histoplasmin in households of patients and controls. The wives of patients were 3 to 5 times more at risk than other adult women. These findings suggest that a common source of infection other than the environment or occupation occurs in the patients' households. This source may be the patient himself. Active disease was not diagnosed in any family member studied.

Accepted for publication June 16, 1973.

^* This research was supported by U.S. Public Health Service grants No. TW-00143 and No. AI-10050 from the National Institutes of Health, Bethesda, Maryland 20014.