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Immunohistologic Alteration of Skin and Ultrastructural Changes of Glomerular Basement Membranes in Leprosy^*

Immunofluorescent "banding" of the dermal-epidermal junction of skin was demonstrated in 3 of 7 patients with lepromatous leprosy by direct immunofluorescence microscopy. The "banding" was caused specifically by deposition of IgM. Within the glomeruli of one patient, dense, amorphous deposits in subendothelial and intramembranous position were also demonstrated by electron microscopy. These preliminary findings suggest that lepromatous leprosy may be associated with immunologic disturbances of both skin and glomerular basement membranes.

Accepted for publication July 14, 1973.

^* This research was supported by grant AI-10094 from the U.S. Public Health Service.

Address reprint requests to: Ward E. Bullock, M.D., Department of Medicine, University of Kentucky College of Medicine, Lexington, Kentucky 40506.

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