AJTMH ASTMH MEMBERSHIP INFORMATION: astmh@astmh.org
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am. J. Trop. Med. Hyg., 23(1), 1974, pp. 78-80
Copyright © 1974 by The American Society of Tropical Medicine and Hygiene

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Damian, R. T.
Right arrow Articles by Fitzgerald, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Damian, R. T.
Right arrow Articles by Fitzgerald, K.

Schistosomiasis Mansoni in Baboons

II. Acquisition of Immunity to Challenge Infection After Repeated Small Exposures to Cercariae of Schistosoma mansoni*

Raymond T. Damian{dagger}, Nathan D. Greene AND Katherine Fitzgerald
Southwest Foundation for Research and Education, P.O. Box 28147, San Antonio, Texas 78284

Eight baboons (Papio cynocephalus) were percutaneously exposed at 3-month intervals to small numbers of Schistosoma mansoni cercariae until a total of 700 was reached over a 3-year period. Fecal egg excretion in all had passed peak levels and was fairly steady or even depressed by about 40 months after the initial exposure. At this time 5 were challenged with 1,000 cercariae each. The other 3, serving as controls, were killed and their worms were counted. The 5 experimental baboons were killed 175 days after challenge and their worm burdens were determined. Post-challenge fecal egg excretion was not increased over pre-challenge levels. The difference in mean percent recoveries of penetrating cercariae in the two groups (experimental, 28.7%; control, 46.2%) was highly significant (P > 0.99 < 0.999). These data indicate that baboons can acquire immunity to S. mansoni, as reflected in fecal egg excretion and worm burdens. The immunity is partial in that neither are all worms destroyed nor is reproduction terminated in the survivors.

Accepted for publication July 21, 1973.


* This investigation was supported by the U.S.-Japan Cooperative Medical Science Program administered by the NIAID, NIH, Department of Health, Education and Welfare, Grant 5 R22 AI08398.


{dagger} Present address: Department of Zoology, The University of Georgia, Athens, Georgia 30602.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1974 by the American Society of Tropical Medicine and Hygiene.