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Comparative Efficacy of one and Two Treatments with Tubercidin against Schistosomiasis Japonica in Monkeys^*

In rhesus monkeys (Macaca mulatta) infected with Schistosoma japonicum (Japanese strain), derived from cercariae obtained from the natural molluscan host Oncomelania hupensis nosophora, a single treatment with the purine nucleoside antibiotic tubercidin (7-deazadenosine) seemed to be as effective as two treatments 1 month apart. The high efficacy of a single treatment with tubercidin against schistosomiasis japonica in monkeys was comparable to that found previously against schistosomiasis mansoni in monkeys. However, the second treatment with tubercidin apparently was responsible for the eradication of the few deformed female worms which presumably survived the first treatment.

Accepted for publication July 21, 1973.

^* This investigation was supported by the United States-Japan Cooperative Medical Science Program administered by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health, Department of Health, Education and Welfare.