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Comparison of Counterimmunoelectrophoresis with Other Serologic Tests in the Diagnosis of Amebiasis^*

The counterimmunoelectrophoresis (CIEP) technique was compared with other serologic tests in regard to sensitivity, specificity and its use as a diagnostic aid for amebic disease. Sera used were from patients with amebic dysentery and amebic liver abscess and from uninfected control persons from the same socio-economic group. Results from indirect hemagglutination, immunodiffusion and immunoelectrophoresis were compared with those from CIEP. The sensitivity and specificity of the CIEP test compared well with the hemagglutination test and was superior to immunodiffusion. The principal advantages of the test are ease in setting up, simplicity of reagents and rapidity of obtaining results.

Accepted for publication June 23, 1973.

^* This work was supported in part by the Veterans Administration Hospital, New Orleans, Research Division.