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Am. J. Trop. Med. Hyg., 23(1), 1974, pp. 15-26
Copyright © 1974 by The American Society of Tropical Medicine and Hygiene

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Experimental Infections with African Trypanosomes

VI. Glomerulonephritis Involving the Alternate Pathway of Complement Activation*

Ray B. Nagle, Peter A. Ward, Herbert B. Lindsley, Elvio H. Sadun, Anthony J. Johnson, Robert E. Berkaw AND Paul K. Hildebrandt
Departments of Experimental Pathology and Medical Zoology, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, D.C. 20012, and Department of Pathology, University of Connecticut Health Center, Farmington, Connecticut 06032

Rhesus monkeys infected with Trypanosoma rhodesiense developed a proliferative glomerulonephritis associated with glomerular deposits consisting of the third component of complement (C3), properdin, and IgM. None of the glomerular deposits contained IgG or IgA. The pattern of deposits as revealed by immunofluorescence was granular. Sera from animals with glomerulonephritis were hypocomplementemic; by radial immunodiffusion some animals showed depression of C3 but not C4 levels. These findings suggest that the glomerulonephritis associated with trypanosomal infections in monkeys is related to deposition of immunologically important serum proteins, two of which represent components in an alternate pathway of complement activation. Trypanosomiasis in the rhesus monkey appears to be a valuable model for studies on the pathogenesis of glomerular injury.

Accepted for publication August 4, 1973.


* This work was supported in part by NIH Grant No. AI09651.






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Copyright © 1974 by the American Society of Tropical Medicine and Hygiene.