AJTMH Transactions of the Royal Society of Tropical Medicine and Hygiene
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Am. J. Trop. Med. Hyg., 23(1), 1974, pp. 118-130
Copyright © 1974 by The American Society of Tropical Medicine and Hygiene

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Studies on the Sequential Immunization against Group B Arboviruses in Squirrel Monkeys, Cynomolgus Monkeys, Rhesus Monkeys, and Chimpanzees*

Winston H. Price, Jordi Casals AND Walter O'Leary
Kenneth F. Maxcy Laboratories, Department of Epidemiology, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland 21205, and Yale Arbovirus Research Unit, Yale University School of Medicine, Department of Epidemiology and Public Health, New Haven, Connecticut 06510

Squirrel monkeys, cynomolgus monkeys, rhesus monkeys and chimpanzees produced very broad and high hemagglutination-inhibition (HI) responses against group B arbovirus antigens when vaccinated with the sequential immunization procedure consisting of live 17D yellow fever virus, live attenuated strain of Langat virus followed by a live attenuated strain of dengue 2 virus. All such primates were protected against challenges with dengue viruses (dengue 1 virus in the case of squirrel monkeys and dengue 4 virus for the other three primate species) as determined by viremia studies and lack of HI antibody booster responses after challenges. The four vaccinated primate species were also protected against challenges with St. Louis encephalitis virus as determined by viremia studies and absence of histologic lesions in the central nervous system. Chimpanzees who had acquired group B arbovirus antibodies in nature responded with very broad and high HI antibodies against group B arbovirus antigens when vaccinated with the 3-virus sequential immunization and were immune to challenges with dengue 4 virus and St. Louis encephalitis virus. The protection against dengue viruses is discussed.

Accepted for publication July 28, 1973.


* This work was supported by the Office of the Surgeon General, Department of the Army, Contract No. DA-49-193-MD-2398.






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Copyright © 1974 by the American Society of Tropical Medicine and Hygiene.