AJTMH Transactions of the Royal Society of Tropical Medicine and Hygiene
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Am. J. Trop. Med. Hyg., 23(1), 1974, pp. 1-7
Copyright © 1974 by The American Society of Tropical Medicine and Hygiene

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Response to Treatment in Man of Multidrug Resistant Plasmodium Falciparum from Panama

Richard H. Glew, Louis H. Miller, William E. Collins, Willam A. Howard*, David J. Wyler, Enrique Chaves-Carballo{dagger} AND Franklin A. Neva
Section on Malaria, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, U.S. Penitentiary, Atlanta, Georgia 30315, and Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, Maryland 20014

A strain of Plasmodium falciparum isolated in the Republic of Panama in March 1972 was transferred to the Unit on Human Malaria (LPD, NIAID, NIH) in Atlanta, Georgia. Studies in eight non-immune prisoner volunteers demonstrated that infections with this Panama II strain of P. falciparum recrudesced following treatment with chloroquine 1.5 g (base), amodiaquine 1.4 g (base), chlorguanide 1.3 g (base) over 5 days, or quinine 11.34 g (base) over 7 days. Parasitemia increased during therapy with pyrimethamine 150 mg over 3 days. Infections were cured by treatment with quinine for 10 days (16.2 g base) or by combination therapy with sulfadiazine (10 g in 5 days) plus pyrimethamine (150 mg in 3 days).

Accepted for publication June 23, 1973.


* Present address: Mayo Clinic, Rochester, Minnesota 55901.


{dagger} Present address: Mayo Graduate School of Medicine, Rochester, Minnesota 55901, formerly of Gorgas Hospital, Ancon, Canal Zone.






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Copyright © 1974 by the American Society of Tropical Medicine and Hygiene.