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Am. J. Trop. Med. Hyg., 21(6), 1972, pp. 979-984
Copyright © 1972 by The American Society of Tropical Medicine and Hygiene

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Experimental Studies with White-Tailed Deer and Four California Group Arboviruses (La Crosse, Trivittatus, Snowshoe Hare, and Jamestown Canyon)*

Charles J. Issel, Daniel O. Trainer{dagger} AND Wayne H. Thompson
Departments of Veterinary Science and Preventive Medicine, University of Wisconsin, Madison, Wisconsin 53706

Prototype strains of four California group arboviruses were subcutaneously inoculated into 26 white-tailed deer (Odocoileus virginianus). Subsequent viremia and antibody data were the criteria used to evaluate deer as natural hosts and/or indicators for La Crosse (LAC), Trivittatus (TVT), snowshoe hare (SSH), and Jamestown Canyon (JC) viruses. Viremia was detected in 7 of 11 deer inoculated with LAC virus, 1 of 3 with TVT virus, 0 of 3 with SSH virus, and 8 of 9 with JC virus. Viremia with LAC and TVT viruses were of low titer and short duration (1 day), while JC virus viremia persisted for 4 to 5 days, with a peak titer of 3.4 Log10 SMICLD50/0.02 ml. Detectable tissue culture neutralization (TCN) antibodies to the homologous virus persisted for at least 90 days in 9 of 10 surviving deer inoculated with LAC virus, 1 of 3 with TVT virus, 0 of 3 with SSH virus, and 8 of 8 with JC virus. The sera reacted in highest titers to the homologous viruses, and highest titered cross-reactions were noted following LAC virus inoculation. It was concluded that white-tailed deer could be natural hosts for JC virus, and may serve as useful indicators for JC and LAC virus activity in nature.

Accepted for publication June 3, 1972.


* This study was supported in part by a post-doctoral fellowship to the senior author from the National Institute of Allergy and Infectious Diseases (2-F02-AI46542-02) and by a Public Health Service Research Grant (CC00203) from the Center for Disease Control, Atlanta, Georgia.


{dagger} Present address: Dean, College of Natural Resources, University of Wisconsin, Stevens Point, Wisconsin 54481.






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Copyright © 1972 by the American Society of Tropical Medicine and Hygiene.