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Raised Levels of Serum IgE in Human Helminthiases^*

Somei Kojima, Muneo Yokogawa AND Tomio Tada

The concentration of serum IgE in four human helminthiases was determined by an indirect single radial immunodiffusion method. Whereas in most normal adults serum levels of IgE were below 300 units/ml, raised levels of IgE were found in patients infected with helminths. Mean values were 1,210 units/ml in 60 cases of schistosomiasis japonica, 3,400 units/ml in 5 cases of paragonimiasis, 2,960 units/ml in 4 cases of fascioliasis hepatica, and 570 units/ml in 10 cases of hookworm infection. The results clearly indicate that an increase of serum IgE concentration occurs in various helminthic infections, although the significance of this is still obscure.

Accepted for publication May 16, 1972.

^* This study was supported in part by a grant-in-aid for fundamental scientific research, No. 7088, from the Education Ministry of Japan.

Present address: Department of Pathology, New York University Medical Center, New York, N.Y. 10016.