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Effects of Minocycline against Chloroquine-Resistant Falciparum Malaria^*

D. Willerson, Jr., K. H. Rieckmann, P. E. Carson AND H. Frischer

The antimalarial effects of minocycline, a semi-synthetic tetracycline, were evaluated in chloroquine-resistant Plasmodium falciparum infections. Nine volunteers infected with the Vietnam (Marks) strain were cured after each received a 7-day course of minocycline. Two additional subjects infected with the same Vietnamese strain were cured after each received a combination of minocycline and quinine. Minocycline protected 16 of 18 volunteers after challenge with Anopheles stephensi mosquitoes infected with chloroquine-resistant strains of P. falciparum. Eleven men were protected against a single challenge by mosquitoes infected with the Cambodia (Buchanan) strain. Five of seven volunteers were protected against a single challenge by mosquitoes infected with the Vietnam (Marks) strain. No sporontocidal or gametocytocidal effects occurred in one volunteer who received a 7-day course of minocycline.

Accepted for publication May 13, 1972.

^* The data in this paper were presented to the Commission on Malaria of the Armed Forces Epidemiological Board, Walter Reed Army Institute of Research, Washington, D. C. on 28 November 1971.

Present address: 4627 Edmondson, Dallas, Texas 75209.

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