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Am. J. Trop. Med. Hyg., 21(5), 1972, pp. 582-586
Copyright © 1972 by The American Society of Tropical Medicine and Hygiene

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Royal Farm Virus: A new Tickborne Group B Agent Related to the RSSE Complex*

R. E. Williams, J. Casals, M. I. Moussa AND H. Hoogstraal
U. S. Naval Medical Research Unit No. 3 (NAMRU-3), c/o U. S. Interests Section, Spanish Embassy, Cairo, Egypt, and Yale Arbovirus Unit, Yale University School of Medicine, New Haven, Connecticut 06510

Royal Farm, a new group B virus from Argas hermanni ticks collected in Kabul Province, Afghanistan, is described. Its group relation through Powassan and Langat viruses is shown by complement fixation (CF) and neutralization tests (N). By CF test it is closely related to Powassan and by N test to Langat. Two isolations, 1 month apart, were made from ticks collected in pigeon shops in Kabul City and the Royal Farm in Kabul Province, respectively. The virus is pathogenic for hamsters but not for weanling guinea pigs and rabbits. Biologically, it differs from Powassan and Langat in its average survival time in 2-day-old mice, in its inability to kill adult mice by the intraperitoneal route, in having titers a minimum of 2 logs lower in suckling mice, and it kills chick embryos by the allantoic, amniotic, and yolk sac routes. Specific immune serum of Langat and Royal Farm reacted only with their homologous antigen in agar gel precipitation tests.

Accepted for publication March 11, 1972.


* This work was supported from Research Projects MF 12.524.009-3021B and MR 005.09-0037, Bureau of Medicine and Surgery, Department of the Navy, Washington, D. C., and by the Yale Arbovirus Research Unit, Yale University, New Haven, Connecticut.

The opinions and assertions contained herein are the private ones of the authors and are not to be construed as official or as reflecting the views of the Department of the Navy, the naval service at large, Yale University, or the Egyptian Ministry of Health.






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Copyright © 1972 by the American Society of Tropical Medicine and Hygiene.