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Am. J. Trop. Med. Hyg., 21(4), 1972, pp. 415-420
Copyright © 1972 by The American Society of Tropical Medicine and Hygiene

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Serum and Cerebrospinal Fluid in Eosinophilic Meningoencephalitis: Immunoglobulins and Antibody to Angiostrongylus Cantonensis*

Rachaneepas Tungkanak{dagger}, Stitaya Sirisinha AND Sompone Punyagupta
Department of Microbiology, Faculty of Science, and Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 4, Thailand

Serum and cerebrospinal fluid (CSF) from patients with eosinophilic meningoencephalitis were analyzed for changes in the protein profile and for antibodies to an Angiostrongylus cantonensis extract to seek evidence for a local immune response in the central nervous system. The results showed increased serum IgG and increased CSF total protein, albumin, IgG, IgA, and IgM. Although the CSF immunoglobulin levels were much lower than the corresponding serum levels, antibody activity of both fluids to A. cantonensis extract were similar. These findings are compatible with the idea that CSF antibodies may be synthesized locally within the central nervous system in response to antigenic stimulation.

Accepted for publication January 11, 1972.


* This investigation was supported in part by a research grant from the Division of Medical Sciences of the National Research Council of Thailand, by Mahidol University, and by the Rockefeller Foundation.

Address reprint requests to: Stitaya Sirisinha, Department of Microbiology, Faculty of Science, Mahidol University, Bangkok 4, Thailand.


{dagger} A portion of these studies was submitted by Rachaneepas Tungkanak to the Faculty of Graduate Studies, Mahidol University, in partial fulfillment of the requirements for the degree of Master of Science.






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Copyright © 1972 by the American Society of Tropical Medicine and Hygiene.