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Community Control of Amebic Disease by Periodic Mass Treatment with Metronidazole

Max J. Miller^*, Frank Scott AND Edward F. Foster

Results of a drug treatment program for control of amebic disease in an Amerindian reservation in northern Canada are reported. The population of approximately 350 was treated with metronidazole for a 12-month period. The drug was given in a single dose monthly for the first 3 months and bimonthly thereafter. Good results were achieved, with a 7-fold reduction from the 27 and 28 cases, respectively, seen during the two previous consecutive 12-month periods to only 4 cases during the 12 months of periodic treatments. A neighboring reservation, which served as a control, did not show a similar reduction in amebic disease over the same period of time. The drug was generally well tolerated except by infants and young toddlers, who showed a high incidence of vomiting. This improved when the dosage was reduced.

Accepted for publication January 24, 1972.

^* Department of Tropical Medicine and Parasitology, Tulane University, School of Public Health and Tropical Medicine, New Orleans, Louisiana 70112.

Loon Lake, Saskatchewan.

Indian Health Services, Department of National Health and Welfare, North Battleford, Saskatchewan.