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Pre-Erythrocytic Rodent Malaria, Plasmodium Berghei—Prevention of Development in the Ethionine Fatty Liver^*

Pre-erythrocytic development of rodent malaria, Plasmodium berghei, is prevented in vivo in young female rats in a standard model of metabolic liver cell injury, the ethionine fatty liver. Treatment with ethionine, methionine, and adenosine permitted somewhat impaired development.

Accepted for publication November 20, 1971.

^* Supported in part by a Society of the Sigma Xi Grant-in-Aid of Research to the senior author, 1970, and in part by U.S. Public Health Service Grants No. 1-SO1-FR-05370-02 to Northwestern University, and No. NIH-AI-02753 to the University of Notre Dame.

Reprints are available from the Vector Biology Laboratory, Department of Biology, University of Notre Dame, Notre Dame, Indiana 46556.