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Am. J. Trop. Med. Hyg., 21(3), 1972, pp. 272-281
Copyright © 1972 by The American Society of Tropical Medicine and Hygiene

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Experimental Infection with Plasmodium Falciparum in Aotus Monkeys

II. Observations on Host Pathology*

Helen Roland Jervis, Helmuth Sprinz, Anthony J. Johnson AND Bruce T. Wellde
Departments of Pathology and Medical Zoology, Divisions of Experimental Pathology and Communicable Diseases and Immunology, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, D.C. 20012

Organs from more than 43 Aotus monkeys inoculated with 1 x 104 or 1 x 108 erythrocytes infected with chimpanzee-derived Plasmodium falciparum (Camp strain) and from 9 control monkeys injected with saline were studied by histologic and histochemical methods. Parasitemia at the time of death varied from 5% to 74%. Pathologic changes observed in various organs of the infected monkeys were generally mild and nonspecific. Most conspicuous were RBC's parasitized with late stages of Plasmodia which tended to marginate on the walls of blood vessels or to form aggregates packing, at times, the capillaries of deep organs. No intravascular thrombi were demonstrable and no tissue lesions accompanied capillary packing. Characteristic of the malaria-infected Aotus was the generally moderate response of the RE system; specifically, stimulated Kupffer's cells and swollen pulmonary endothelial cells were not very numerous. Likewise, the spleen, while enlarged, still maintained the normal structure of the red pulp. However, malpighian follicles showed marked hyperplasia and marked proliferation of immunoblasts. Otherwise, organ involvement, such as cerebral hemorrhages or glial scars, ruptured spleen, hemoglobinuric nephrosis, etc., was not observed. It is suspected that death was due to hypovolemia and shock.

Accepted for publication December 6, 1971.


* This is Publication No. 938 in the Army Research Program in Malaria.






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Copyright © 1972 by the American Society of Tropical Medicine and Hygiene.