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Inhibitors of Western and Venezuelan Equine Encephalitis Viruses in Cattle Sera from Hawaii^*

W. F. Scherer, W. C. Reeves, J. L. Hardy AND T. Miura

Apparently, nonspecific inhibitors of Western and Venezuelan equine encephalitis viruses were found in cattle sera from Hawaii by plaque-reduction neutralization (N) tests in avian cell cultures and by hemagglutination-inhibition (HI) tests. Yet the islands were presumably free of these viruses in 1964 to 1966 when the sera were collected, and no inhibitors were detected in sera from Hawaiian goats and pigs and in more than 98 percent of sheep sera. Specific HI and N, but not complement-fixing, antibodies, developed in the serum of one cow sequentially inoculated with Sagiyama, Western and Eastern equine encephalomyelitis viruses of group A.

Accepted for publication August 28, 1971.

^* Supported in part by research contract number DA-49-193-MD-2295 from the U.S. Army Medical Research and Development Command, under sponsorship of the Commission on Viral Infections of the Armed Forces Epidemiological Board; and in part by U. S. Public Health Service Training Grants 2E-188 and 5-T1-AI-231 and Research Grant AI-03028 from the National Institute of Allergy and Infectious Diseases, National Institutes of Health.

Present address: Department of Hygiene, University of Tokyo Medical School, Tokyo, Japan.