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Am. J. Trop. Med. Hyg., 20(5), 1971, pp. 655-660
Copyright © 1971 by The American Society of Tropical Medicine and Hygiene

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Plasmodium Falciparum Malaria

Ultrastructure of Parasitized Erythrocytes in Cardiac Vessels*

Sarah A. Luse{dagger} AND Louis H. Miller{ddagger}
Department of Anatomy and Division of Tropical Medicine, College of Physicians and Surgeons of Columbia University, New York, N. Y. 10032

In Aotus trivirgatus, the night monkey, schizonts and mature trophozoites of Plasmodium falciparum are concentrated in myocardium, adipose tissue, and skeletal muscle where parasitized red cells line the veins and block some capillaries. Electronmicroscopy reveals gross distortion of host red cells with numerous ultramicroscopic abnormalities of the red cell surface. Ultrastructural lesions of the red cell membrane have been demonstrated in cells infected with Plasmodium coatneyi and, as we have shown, in A. trivirgatus infected with P. falciparum. In infections with these parasites deep vascular schizogony is a prominent feature. The superficial alterations of the parasitized cells appear to be sites of attachment to venous endothelium and to other parasitized erythrocytes, thus explaining the paucity of circulating cells with maturing parasites in falciparum malaria.

Accepted for publication March 4, 1971.


* This work was supported in part by a grant from the Institute of General Medical Science, GM 15289 and by a training grant of the Institute of Allergy and Infectious Diseases (2-TO1-AI-00055 and AI-08718) National Institutes of Health, Bethesda, Md.


{dagger} Dr. Sarah A. Luse died 28 December 1970.


{ddagger} Career Development Awardee, NIAID, AI-23084.




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Copyright © 1971 by the American Society of Tropical Medicine and Hygiene.