HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Blewett, T. M. Articles by Soulsby, E. J. L. Search for Related Content PubMed PubMed Citation Articles by Blewett, T. M. Articles by Soulsby, E. J. L.

Cutaneous Leishmaniasis in the Guinea Pig

DELAYED-TYPE HYPERSENSITIVITY, LYMPHOCYTE STIMULATION, and INHIBITION OF MACROPHAGE MIGRATION^*

T. M. Blewett, D. M. H. Kadivar AND E. J. L. Soulsby

Delayed hypersensitivity phenomena in cutaneous leishmaniasis of the guinea pig, caused by Leishmania enriettii, were investigated with an antigen prepared from promastigotes grown in culture. Cutaneous delayed-type hypersensitivity was shown to persist for several months after resolution of lesions. Two in vitro correlates of delayed hypersensitivity, blastoid transformation of peripheral blood lymphocytes and the inhibition of migration of peritoneal macrophages, were also positive. Macrophage inhibition persisted several months after resolution. These results suggest that immunity to this form of leishmaniasis is cell-mediated.

Accepted for publication January 21, 1971.

^* This study was supported by Research Grant AI-06262 from the Public Health Service.

Present address: School of Medicine, Pahlavi University, Shiraz, Iran.

This article has been cited by other articles:

				D. Kadivar and E. Soulsby Model for disseminated cutaneous leishmaniasis Science, December 19, 1975; 190(4220): 1198 - 1200. [PDF]