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Pathologic Effects of Schistomiasis in Ibadan, Western State of Nigeria

II. Pathogenesis of Lesions of the Bladder and Ureters^*

F. Von Lichtenberg, G. M. Edington, I. Nwabuebo, J. R. Taylor^¶ AND J. H. Smith^||

One hundred thirty-five cases of urinary schistosomiasis found in 637 unselected autopsies from Ibadan, Nigeria, were studied by macroscopic and microscopic examination, urography, and tissue digestion techniques. The macroscopic and microscopic appearance of urinary tract lesions due to Schistosoma haematobium are described. Evidence favoring progression of schistosomal lesions from polypoid patches to sandy patches is presented, and changes in tissue egg-load with progression are described. A direct relation was found between intensity of infection, severity of disease, and prevalence of complications. Determinants of obstructive uropathy in urinary schistosomiasis are evaluated.

Accepted for publication August 19, 1970.

^* This work was supported by grants from the W.H.O. Section on Parasitic Diseases (G. M. Edington) and by Contract DA-49-193-MD-2253 of the Armed Forces Epidemiological Board, Office of The Surgeon General, and Grant AI-02631 of the United States-Japan Cooperative Medical Science Program administered by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health, Department of Health, Education and Welfare (F. von Lichtenberg).

Department of Pathology, Peter Bent Brigham Hospital, 721 Huntington Avenue, Boston, Massachusetts 02115.

Department of Pathology, University College Hospital, Ibadan, Nigeria.

Department of Pathology, University of Ibadan, Ibadan, Nigeria.

^¶ Present address: Winnipeg General Hospital, 700 William Avenue, Winnipeg 3, Manitoba, Canada.

^|| Present address: NAMRU-3, Cairo, Egypt, FPO New York, N. Y. 09527.

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