HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Kass, L. Articles by Carson, P. E. Search for Related Content PubMed PubMed Citation Articles by Kass, L. Articles by Carson, P. E.

Blastoid Transformation of Lymphocytes in Falciparum Malaria

Lawrence Kass^*, Darrell Willerson, Jr., Karl H. Rieckmann AND Paul E. Carson

Small peripheral-blood lymphocytes from patients partially immune to infections with either the Malayan (Camp.) or Uganda I strain of Plasmodium falciparum underwent transformation to large, ameboid, pyroninophilic blasts when cultured in vitro with extracts of P. falciparum gametocytes or trophozoites. Lymphocytes from uninfected persons did not undergo blastoid transformation when exposed to the same extracts. This phenomenon was demonstrable not only during patent parasitemia but also for as long as 2 years after radical cure of the malaria infection. Polyacrylamide-disc electrophoresis of the gametocyte extracts demonstrated protein bands not present in normal hemolysates.

Accepted for publication September 8, 1970.

^* Present address: Department of Internal Medicine, Simpson Memorial Institute, Univeristy of Michiga, Ann Arbor, Michigan.

Recipient of a Research and Career Development Award from the United States Public Health Service.