AJTMH Transactions of the Royal Society of Tropical Medicine and Hygiene
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Am. J. Trop. Med. Hyg., 20(1), 1971, pp. 95-100
Copyright © 1971 by The American Society of Tropical Medicine and Hygiene

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Treatment of Intestinal Capillariasis with Thiabendazole, Bithionol, and Bephenium*

George E. Whalen{dagger}, Eugene B. Rosenberg, Robert A. Gutman, John Cross, James W. Fresh, Thomas Strickland AND Cesar Uylangco
Department of Clinical Investigation, U. S. Naval Research Unit No. 2, Taipei, Taiwan and San Lazaro Hospital and Department of Health, Republic of the Philippines

Treatment of intestinal capillariasis, a newly recognized disease in man, was evaluated in 26 patients during an epidemic in the Philippines. Before this study, no effective treatment was available and the case mortality rate was high. Capillaria philippinensis parasites were eliminated from all 26 patients treated with thiabendazole, and 24 had dramatic clinical improvement. Long-term therapy with thiabendazole sharply decreased the case mortality rate, from 35% to less than 4%. The relapse rate that used to be high among patients treated less than 1 week was prevented by daily administration of the drug for 3 or 4 weeks. Over 75% of the patients observed for 18 months remained asymptomatic after using thiabendazole.

Accepted for publication March 4, 1970.


* This work was supported by funds provided by the Bureau of Medicine and Surgery, U. S. Department of the Navy, for work unit MR005.09-0090, and by the Geographic Medicine Branch, National Institutes of Allergy and Infectious Diseases, U. S. Public Health Service.


{dagger} Presently at Columbia Hospital, Wood Veterans Administration Center and Marquette School of Medicine, 5000 West National Avenue, Milwaukee, Wisconsin 53193.

Please address requests for reprints to Publications Office, NAMRU-2, Box 14, APO San Francisco, California 96263.






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Copyright © 1971 by the American Society of Tropical Medicine and Hygiene.