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Am. J. Trop. Med. Hyg., 2(6), 1953, pp. 989-999
Copyright © 1953 by The American Society of Tropical Medicine and Hygiene

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A Clinical Study of Primaquine (S. N. 13,272) in the Treatment of Malaria among the Miskito Indians of Nicaragua1

A. David Thaeler, Jr.2, John Arnold3 AND Alf S. Alving4
Hospital Ruth C. S. Thaeler de la Mision Morava, Bilwaskarma, Nicaragua, and the Malaria Research Unit, Department of Medicine, University of Chicago, Chicago, Illinois

Since 1948, primaquine, a close relative of pamaquine, the historically important curative antimalarial agent, has been the subject of intensive clinical study at Stateville Penitentiary (Edgcomb et al., 1950; Hockwald et al., 1952; Clayman et al., 1952). More recently primaquine has been used on a large scale among military personnel (Alving et al., 1952). These studies have shown that primaquine is safe and practical for mass prophylaxis and therapy of malaria in nonimmune Caucasians and Negroes in a nonendemic area, and as such is the drug of choice for curative treatment of relapsing malaria (Alving et al., 1953).

There remain, however, two very important problems: (1) testing the tolerance of tropical native peoples to primaquine and (2) measuring the response of field infections to treatment with that drug. These problems involve several factors not present in previous studies. Very few tropical populations are well nourished.


1 This study was supported by Army Contract No. DA-49-007-MD-20 between the University of Chicago and the Medical Research and Development Board, Office of the Surgeon General, Department of the Army. It was carried out in Nicaragua at the Hospital Ruth C. S. Thaeler, de la Mision Morava, Bilwaskarma, Nicaragua, on invitation of the Nicaraguan government. Part of the publication costs was borne by Winthrop-Stearns, Incorporated, New York.


2 Hospital Ruth C. S. Thaeler, de la Mision Morava, Bilwaskarma, Nicaragua.


3 Major MC AUS, Medical Nutrition Laboratory, Office of the Surgeon General, Department of the Army.


4 Malaria Research Unit, Department of Medicine, University of Chicago.






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Copyright © 1953 by the American Society of Tropical Medicine and Hygiene.