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Korean Vivax Malaria

V. Cure of the Infection by Primaquine Administered during Long-term Latency^*

In a study of the curative activity of primaquine administered during long-term latency of Korean vivax malaria, 294 soldiers, exposed to infection in the summer of 1951 were treated early in April, 1952 with 15 mg. of primaquine daily for 14 days. A control group of 331 men was given a placebo. None of the men treated with primaquine developed malaria during the next six months; 17.5 per cent of those given the placebo did develop malaria during the same period.

^* These studies were conducted at Fort Benning, Georgia, Fort Knox, Kentucky, Fort Dix, New Jersey, and Camp Breckenridge, Kentucky. Most of the primaquine was supplied gratuitously by Eli Lilly & Co. for which thanks are extended. This work was supported (in part) by the Medical Research and Development Board, Office of the Surgeon General, Department of the Army.

¹ Laboratory of Tropical Diseases, National Microbiological Institute, National Institutes of Health.

² Department of Medicine, University of Chicago.

³ Department of Medicine, University of Pennsylvania.

⁴ First Lieut., Major, Captain, Captain, Lt. Colonel, Captain, Colonel, and Lt. Colonel, respectively, MC, U.S.A.