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Am. J. Trop. Med. Hyg., 2(6), 1953, pp. 1000-1001
Copyright © 1953 by The American Society of Tropical Medicine and Hygiene

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A Further Study of the Toxicity of Pyrimethamine (Daraprim) in Man1

A. V. Myatt, G. Robert Coatney, Thomas Hernandez AND Herbert W. Burton
Laboratory of Tropical Diseases, National Microbiological Institute, National Institutes of Health, Bethesda 14, Maryland

Reported therapeutic tests show that pyrimethamine is an effective suppressant for malaria in dosage of 25 mg. single dose weekly. Our studies reported here and previously (Coatney et al., 1953) indicate that this dosage may be given safely to white or colored races without untoward reactions, barring possible cases of idiosyncrasy.


1 The work reported here was conducted under a contract between the Office of the Surgeon General, Department of the Army, and the National Institutes of Health.






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