AJTMH Transactions of the Royal Society of Tropical Medicine and Hygiene
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Am. J. Trop. Med. Hyg., 2(5), 1953, pp. 788-795
Copyright © 1953 by The American Society of Tropical Medicine and Hygiene

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Studies in Human Malaria

XXXIII. The Toxicity of Pyrimethamine (Daraprim) in Man

Albert V. Myatt, Thomas Hernandez AND G. Robert Coatney
Laboratory of Tropical Diseases, National Microbiological Institute, National Institutes of Health, Bethesda 14, Maryland

Pyrimethamine (Daraprim) was given to 12 healthy volunteers for 49 days at a dosage of 25 mg. single dose daily. Six subjects developed a megaloblastic type of anemia with rapid remission when the drug was stopped.






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Copyright © 1953 by the American Society of Tropical Medicine and Hygiene.