HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Coatney, G. R. Articles by Cooper, W. C. Search for Related Content PubMed PubMed Citation Articles by Coatney, G. R. Articles by Cooper, W. C.

Studies in Human Malaria

XXXII. The Protective and Therapeutic Effects of Pyrimethamine (Daraprim) Against Chesson Strain Vivax Malaria¹

This study was undertaken to evaluate the protective and therapeutic efficacy of pyrimethamine (Daraprim) against Chesson strain Plasmodium vivax in human volunteers. The drug was highly effective as a suppressive agent, 0.8 to 25 mg. gave complete protection during drug administration; it was less efficient when used for therapy of acute attacks. Pyrimethamine does not appear to be a true causal prophylactic although prolonged delays before patent parasitemia suggested some deleterious effect against early tissue stages of the parasite. Weekly administration of the drug for 8 or more weeks resulted in suppressive cure of many infections. Probably the greatest usefulness of the drug will be for routine suppression.

¹ The work reported here and in the two papers that follow was conducted under a contract between the Office of the Surgeon General, Department of the Army, and the National Institutes of Health.

This article has been cited by other articles:

				A. V. MYATT and G. R. COATNEY PRESENT CONCEPTS AND TREATMENT OF PLASMODIUM VIVAX MALARIA Arch Intern Med, February 1, 1954; 93(2): 191 - 196. [Abstract] [PDF]