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Am. J. Trop. Med. Hyg., 2(1), 1953, pp. 64-69
Copyright © 1953 by The American Society of Tropical Medicine and Hygiene

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Antibiotics in the Treatment of Toxoplasmosis

Don E. Eyles AND Nell Coleman
Laboratory of Tropical Diseases, Microbiological Institute, National Institutes of Health, 874 Union Avenue, Memphis 3, Tennessee

The experiments described demonstrated statistically significant activity against mouse toxoplasmosis for aureomycin, terramycin, fumagillin, and chloramphenicol; however, with the possible exception of aureomycin, none is believed to be sufficiently active to be of practical importance. Aureomycin produced apparent cures in some mice, but only at extremely high dosages, higher than those attainable in man. Comparison of the results of these experiments with those of others indicates the existence of strains of Toxoplasma differing in their response to this drug.

Viomycin, Neomycin, Fracidin, Prodigiosin and R-2007 produced no effect on mouse toxoplasmosis under the conditions of our experiments.






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Copyright © 1953 by the American Society of Tropical Medicine and Hygiene.