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Natural Resistance to Plague: Genetic Basis in the Vole (Microtus Californicus)

California voles, Microtus californicus, from separate field populations were bred and reared in the laboratory. One group was susceptible and the other highly resistant to plague. Progeny of parental strains, as well as reciprocal F₁ and back-cross matings, were titrated for susceptibility to Yersinia pestis Colorado 353. The results of susceptibility titrations indicate that inheritance of natural resistance to plague is multigenic, similar to Gowen's findings for mouse typhoid. Increase in resistance is linked to dominance. Differences in resistance appear to be associated primarily with changes in phagocytic activity.

Accepted for publication June 3, 1970.

^* Current address: National Animal Disease Laboratory, USDA, P. O. Box 70, Ames, Iowa 50010.