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Am. J. Trop. Med. Hyg., 19(6), 1970, pp. 1015-1019
Copyright © 1970 by The American Society of Tropical Medicine and Hygiene

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Natural Resistance to Plague: Genetic Basis in the Vole (Microtus Californicus)

William T. Hubbert* AND Martin I. Goldenberg
Zoonoses Section, Ecological Investigations Program, National Communicable Disease Center, Health Services and Mental Health Administration, PHS, DHEW, P. O. Box 551, Fort Collins, Colorado 80521

California voles, Microtus californicus, from separate field populations were bred and reared in the laboratory. One group was susceptible and the other highly resistant to plague. Progeny of parental strains, as well as reciprocal F1 and back-cross matings, were titrated for susceptibility to Yersinia pestis Colorado 353. The results of susceptibility titrations indicate that inheritance of natural resistance to plague is multigenic, similar to Gowen's findings for mouse typhoid. Increase in resistance is linked to dominance. Differences in resistance appear to be associated primarily with changes in phagocytic activity.

Accepted for publication June 3, 1970.


* Current address: National Animal Disease Laboratory, USDA, P. O. Box 70, Ames, Iowa 50010.






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Copyright © 1970 by the American Society of Tropical Medicine and Hygiene.