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Effect of Macrophage Engulfment and Temperature on the Transformation Process of Leishmania Donovani^*

The effect of engulfment by hamster macrophages, and of temperature, on the transformation of Leishmania donovani was investigated using NNN-cultured leptomonads, and hamster-spleen-derived Leishman-Donovan bodies. Intracellular localization of the parasities promoted transformation from leptomonad to Leishman-Donovan bodies, whereas extracellular localization promoted the reverse transformation. Temperature appeared to be a selective, rather than an inductive, factor in the transformation process. The development and maintenance of the parasite in the Leishman-Donovan body stage depended upon an intracellular localization, and upon the integrity of the macrophage, rather than the temperature of incubation.

Accepted for publication December 30, 1969.

^* This investigation was supported in part by a Faculty Research Grant of San Jose State College, and a grant from the Brown-Hazen Fund of the Research Corporation, New York, N. Y.