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Lassa Fever, a New Virus Disease of Man from West Africa

I. Clinical Description and Pathological Findings

John D. Frame^*, John M. Baldwin, Jr., David J. Gocke AND Jeanette M. Troup

Lassa Fever, a hitherto unknown virus disease from Nigeria, caused the death of two missionary-nurses and the grave illness of a third. The onset is gradual with fever, weakness, myositis and ulcerative pharyngitis, progressing to symptoms of myocarditis, pneumonitis and pleuritis, encephalopathy, and evidences of a hemorrhagic diathesis. It is characterized in the early stages by moderate leukopenia, with increase of immature neutrophilic elements. It may be transmitted directly from person to person; the incubation period is about a week. It is likely to be of increasing public-health importance as travel to the interior parts of Nigeria increases, and as the area is developed because of future population pressures.

Accepted for publication January 20, 1970.

^* Please address requests for reprints to Dr. John Frame, Division of Tropical Medicine, School of Public Health and Administrative Medicine, 630 West 168th Street, New York, N. Y. 10032.

Dr. Troup died on 18 February 1970, presumably of Lassa fever, in Jos, Nigeria.

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