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Long-Term Persistence of Modoc Virus in Hamster-Kidney Cells

In vivo and in vitro Demonstration^*

Modoc virus, a member of group B of the arthropod-borne viruses, produced an infection in a hamster with excretion of the virus in the urine for a period of 5 months. The presence of the virus in the kidney in a state of latency was demonstrated by cell culture of kidney tissue at 14 months after inoculation with the virus. The blood serum contained a high level of antibody against the virus. and direct inoculation of the kidney tissue into animals did not reveal active virus.

Accepted for publication December 1, 1969.

^* This work was done as part of the Cooperative Arbovirus Studies, a joint project of The Rockefeller Foundation and the California State Department of Public Health.

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