AJTMH Transactions of the Royal Society of Tropical Medicine and Hygiene
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Am. J. Trop. Med. Hyg., 19(3), 1970, pp. 459-462
Copyright © 1970 by The American Society of Tropical Medicine and Hygiene

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Effect of the Administration of the Antischistosomal Drug Niridazole on Muscle Glycogen Levels of Monkeys*

E. Bueding, D. G. Erickson, L. W. Scheibel, J. Fisher AND J. C. Key
Department of Pathobiology, School of Hygiene and Public Health, and Department of Pharmacology and Experimental Therapeutics, School of Medicine, The Johns Hopkins University, Baltimore, Maryland 21205, and Department of Medical Zoology, Walter Reed Army Institute of Research, Washington, D. C. 20012

Niridazole was administered to 57 rhesus monkeys at a dosage schedule approximating the minimally curative dose for schistosomiasis mansoni of this species. This resulted in a marked depletion of the muscle glycogen stores, which was attributed in part to a reduced food intake due to anorexia produced by the drug and in part to an inhibition of phosphorylase phosphatase, activity bringing about an accumulation of active glycogen phosphorylase. Restoration of muscle glycogen levels to control values was observed about 8 days after discontinuation of drug administration.

Accepted for publication September 2, 1969.


* This investigation was supported by grants AI-03515 and AI-08022 from the National Institutes of Health.






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Copyright © 1970 by the American Society of Tropical Medicine and Hygiene.