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Am. J. Trop. Med. Hyg., 19(1), 1970, pp. 88-93
Copyright © 1970 by The American Society of Tropical Medicine and Hygiene

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Studies of Arthropod-Borne Virus Infections in Chiroptera

VII. Serologic Evidence of Natural Japanese B Encephalitis Virus Infection in Bats*,{dagger},

Teiji Miura, Kohei Toyokawa, Rae Allen AND S. Edward Sulkin
Department of Hygiene and Preventive Medicine, University of Tokyo, Tokyo, Japan, and Department of Microbiology, The University of Texas Southwestern Medical School, Dallas, Texas 75235

Plasma samples from 1,459 bats collected in Japan during 1963–1965 were assayed for serologic evidence of infection with JBE virus by an in vitro plaque-reduction method. Neutralizing antibodies were demonstrated in 8% of the specimens of plasma from bats netted in Honshu and Kyushu, Japan, whereas only 3% of the specimens from bats netted in Hokkaido, the northernmost part of Japan, were positive. Bats with neutralizing antibodies against JBE virus were found with about equal frequency in groups collected during each of the four seasons of the year. Serologic evidence of infection with JBE virus could not be detected by the HI test. Antibodies against JBE virus were also demonstrated in 7% of 275 specimens of plasma tested by the in vivo neutralization test in weanling mice. Similarities between certain characteristics of the immune response of bats to natural and experimental infection with JBE virus are discussed.


* This investigation was conducted under the sponsorship of The Commission on Viral Infections, Armed Forces Epidemiological Board, and was supported by the U. S. Army Medical Research and Development Command, Department of the Army, under Contract No. Da-49-193-MD-2138.


{dagger} Please address requests for reprints to Dr. Sulkin.




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J. Cui, D. Counor, D. Shen, G. Sun, H. He, V. Deubel, and S. Zhang
Detection of Japanese Encephalitis Virus Antibodies in Bats in Southern China
Am J Trop Med Hyg, June 1, 2008; 78(6): 1007 - 1011.
[Abstract] [Full Text] [PDF]


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Copyright © 1970 by the American Society of Tropical Medicine and Hygiene.