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Dichlorvos, an Effective Broad-Spectrum Anthelmintic^*,,,

We wished to evaluate the safety and anthelmintic efficacy for man of dichlorvos (Dichlorman®), a new anthelmintic compound. Clinical, parasitologic, and pharmacologic studies were conducted on 108 hospitalized adult patients. The drug was administered in a granular-resin formulation that permits slow liberation in the intestinal tract. Formalinether (MGL) and Stoll egg-count techniques were employed for evaluation of therapy at different dosage levels. A wide range of laboratory studies was done, with particular emphasis on plasma and red-cell cholinesterase determinations. Despite the fact that the drug caused reduction in plasma cholinesterase levels, no clinical side-effects were observed in the carefully monitored patients, except for brief mild headache in a few. Cure rates of infections, with a single oral dose of 12 mg per kilogram of body weight, were 85.7% for hookworm, 87.8% for Trichuris trichiura, and 77.8% for Ascaris lumbricoides; egg-count reductions in the cases not completely cured were 97.3, 98.5, and 83.7 percent, respectively.

^* Supported, in part, by a research grant from Shell Chemical Company, and, in part, by Public Health Service Grant TW00148 from the National Institute of Allergy and Infectious Diseases.

Presented at the Annual Meeting of the American Society of Tropical Medicine and Hygiene, 1 November 1968, Atlanta, Georgia.

Please address requests for reprints to Dr. J. Clyde Swartzwelder, Department of Tropical Medicine and Medical Parasitology, Louisiana State University Medical Center, 1542 Tulane Avenue, New Orleans, Louisiana 70112.