HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by D'Antonio, L. E. Articles by Mathot, C. Search for Related Content PubMed PubMed Citation Articles by D'Antonio, L. E. Articles by Mathot, C.

Temporal Relation between a Serum Electroadsorbing Fraction and the Course of Acute Plasmodium Berghei Malaria in Rats^*

The temporal relations of a serum electroadsorbing factor (S. E. A. F.) that, quantitatively electroadsorbed from the serum of normal and Plasmodium berghei-infected rats, were determined by a modification of the immunoelectroadsorption (I. E. A.) technique. The S. E. A. F. electroadsorbed independently of the presence of a specific P. berghei antigen. It tended to increase slowly with time in normal rats. It was found to increase markedly and abruptly after the 5th day of P. berghei infection, and its pattern of increase appeared to accompany the typical pattern of acute P. berghei anemia and parasitemia. The S. E. A. F. remained elevated for varying periods after the resolution of infection. Its role in normal and pathophysiologic processes is presently unknown, as is its origin or identity. Its appearance interferes with the I. E. A. test, and reference is made to studies describing a resolution to this difficulty.

^* This study was partially supported by the United States Department of State, Agency for International Development, Contract AID/csd-1432 to Dr. Paul H. Silverman and United States Public Health Service Grant GM08815.