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Dengue Type 3 Virus Isolated from an Antiguan Patient during the 1963–64 Caribbean Epidemic^*

A strain of dengue type 3 virus was isolated from the blood of an Antiguan patient in cell cultures of African green-monkey kidney during studies on a dengue outbreak that occurred in the Caribbean region in 1963 and 1964. The virus was adapted to mice by blind intracerebral passage. Illness appeared in mice at the 11th mouse-brain passage. Four other agents, presumed to be dengue type 3 strains, were isolated from Antiguan patients. Serologic studies on paired serum samples from patients of five Caribbean territories showed that the outbreak was due to a group B arbovirus.

^* The studies and observations on which this paper is based were conducted with the support and under the auspices of the Governments of Trinidad and Tobago, Jamaica, Guyana, and the Eastern Caribbean Territories, the Department of Technical Cooperation of the United Kingdom Government, and The Rockefeller Foundation.